Before Watson and Crick in 1953 Came Friedrich Miescher in 1869

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Friedrich Miescher and the discovery of DNA.

Over the past 60 years, DNA has risen from being an obscure molecule with presumed accessory or structural functions inside the nucleus to the icon of modern bioscience. The story of DNA often seems to begin in 1944 with Avery, MacLeod, and McCarty showing that DNA is the hereditary material. Within 10 years of their experiments, Watson and Crick deciphered its structure and yet another decade ...

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Trans-acting small interfering RNAs (siRNAs) trigger a digital silencing response in Paf1C mutant fission yeast cells. Shown here are individual fission yeast colonies that present two different phenotypes (white or red), although all cells are genetically identical. Cells turn red upon siRNA-directed assembly of heterochromatin at the ade6+ gene. Variegating colonies indicate that descendants ...

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Rags before the riches: Friedrich Miescher and the discovery of DNA

Like many success stories, the career of DNA as the molecule of heredity and icon of modern biology began under somewhat less glamorous circumstances. The story begins in 1844, one hundred years before Avery and his colleagues realised the significance of DNA as the genetic material (see accompanying article), with the birth in Basel of Friedrich Miescher, who went on to discover DNA at the age...

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Watson-Crick D0L Systems

D0L systems constitute the simplest and most widely studied type of Lindenmayer systems. They have the remarkable property of generating their language as a (word) sequence and, consequently, are very suitable for modeling growth properties. In this paper a new type of D0L systems is introduced, where the parallelism presented in L systems is combined with the paradigm of (Watson-Crick) complem...

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In this paper, we introduce a new model of deterministic Watson-Crick automaton namely restricted deterministic WatsonCrick automaton which is a deterministic Watson-Crick automaton where the complementarity string in the lower strand is restricted to a language L. We examine the computational power of the restricted model with respect to L being in different language classes such as regular, u...

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ژورنال

عنوان ژورنال: Genetics

سال: 2020

ISSN: 1943-2631

DOI: 10.1534/genetics.120.303195